The Difference between Traditional Magnetic Stimulation and Microcoil Stimulation: Threshold and the Electric Field Gradient

Brad Roth
4 min readOct 4, 2024

In Chapter 7 of Intermediate Physics for Medicine and Biology, Russ Hobbie and I discuss electrical stimulation of nerves. In particular, we describe how neural excitation depends on the duration of the stimulus pulse, leading to the strength-duration curve.

The strength-duration curve for current was first described by Lapicque (1909) as

where i is the current required for stimulation, is the rheobase [the minimum current required for a long stimulus pulse], t is the duration of the pulse, and is chronaxie, the duration of the pulse that requires twice the rheobase current.

An axon is difficult to excite using a brief pulse, and you have to apply a strong current. This behavior arises because the axon has its own characteristic time, τ (about 1 ms), which is basically the resistance-capacitance (RC) time constant of the cell membrane. If the stimulus duration is much shorter than this time constant, the stimulus strength must increase.

A nerve axon not only has a time constant τ, but also a space constant λ. Is there a similar spatial behavior when exciting a nerve? This is the question my graduate student Mohammed Alzahrani and I addressed in our recent article “The Difference between Traditional Magnetic Stimulation and Microcoil Stimulation: Threshold and the Electric Field Gradient” (Applied Sciences, Volume 14, Article 8349, 2024). The question becomes important during magnetic stimulation with a microcoil. Magnetic stimulation occurs when a pulse of current is passed through a coil held near the head. The changing magnetic field induces an electric field in the brain, and this electric field excites neurons. Recently, researchers have proposed performing magnetic stimulation using tiny “microcoils” that would be implanted in the brain. (Will such microcoils really work? That’s a long story, see here and here.) If the coil is only 100 microns in size, the induced electric field distribution will be quite localized. In fact, it may exist over a distance that’s short compared to the typical space constant of a nerve axon (about 1 mm). Mohammed and I calculated the response of a nerve to the electric field from a microcoil, and found that for a localized field the stimulus strength required for excitation is large.

Figure 6 of our article, reproduced below, plots the gradient of the induced electric field (which, in this case, is the stimulus strength) versus the parameter b (which characterizes the spatial width of the electric field distribution). Note that unlike the plot of the strength-duration curve above, Fig. 6 is a log-log plot.

Figure 6 from Alzahrani and Roth, Appl. Sci., 14:8349, 2024

Our strength-spatial extent curve in Figure 6 for magnetic stimulation is analogous to the strength-duration curve for electrical stimulation if we replace the stimulus duration [t] by the spatial extent of the stimulus b and the time constant τ by the [space] constant λ. Our results in Figure 6 have a “spatial rheobase” value (1853 mV/cm2) for large values of spatial extent b. At small values of b, the value of rises. If we wanted to define a “spatial chronaxie” (the value of b for which the threshold value of rises by a factor of two), it would be about half a centimeter.

To learn more about this effect you can read our paper, which was published open access so its available free to everyone. Some researchers have used a value of found when stimulating with a large coil held outside the head to estimate the threshold stimulus strength using a microcoil. We ended the paper with this warning:

In conclusion, our results show that even in the case of long, straight nerve fibers, you should not use a threshold value of in a microcoil experiment that was obtained from a traditional magnetic stimulation experiment with a large coil. The threshold value must be scaled to account for the spatial extent of the distribution. Magnetic stimulation is inherently more difficult for microcoils than for traditional large coils, and for the same reason, electrical stimulation is more difficult for short-duration stimulus pulses than for long-duration pulses. The nerve axon has its own time and space constants, and if the pulse duration or the extent of the distribution is smaller than these constants, the threshold stimulation will rise. For microcoil stimulation, the increase can be dramatic.

Originally published at http://hobbieroth.blogspot.com.

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Brad Roth
Brad Roth

Written by Brad Roth

Professor of Physics at Oakland University and coauthor of the textbook Intermediate Physics for Medicine and Biology.